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Laurent Corte

Laurent Corte

Professor

Center · CMAT

Discipline(s)
Condensed Matter Physics, Nanosciences, Complex Systems, Molecular Chemistry, Polymers, Solid Mechanics
Topic(s)
Biomaterials, Biomechanics, Polymer, Prosthetics

Keywords

Awards & distinctions

  • 2020 Third Prize in the "ZwickRoell Science Award 2020" for our PNAS paper on adhesion to hydrogels and biological tissues

Team

MEM - Mécanique Expérimentale et Matériaux

Biography

Laurent Corté is a Full Professor of Materials Science at the Centre des Matériaux (MAT). Since 2015, he has also been an associated researcher at the Chimie Moléculaire, Macromoléculaire et Matériaux (C3M) laboratory at ESPCI Paris – PSL. His research focuses on biomedical challenges, investigating how the physics and chemistry of soft matter can be exploited to produce innovative materials with novel or enhanced properties of interest to clinicians and biologists. His work combines experimental approaches and analytical modelling. His main recent projects have explored the mechanics of hydrogel fibres for soft tissue reconstruction, the role of interfacial fluids in hydrogel-tissue adhesion, and the potential of thermosensitive hydrogels for cell encapsulation and delivery. Through collaborations, he has also contributed to computational studies exploring the modelling of the mechanical and biological responses of tissues, such as simulating bone healing and predicting tissue behaviour under mechanical stress. Laurent Corté coordinates several modules at MINES Paris – PSL focusing on health engineering and is the programme director of the PSL Master’s programme in Health Sciences and Technology.

Publication(s)

Projects

  • 2019-2023 NANOBIOTAPE Lead Investigator Bioadhesive membranes based on adsorption of particles
  • 2018-2021 INJECTAPORE Lead Investigator Injectable gels with controlled-porosity for cell therapies
  • 2019-2021 LIGAGEL_CLOSER_TO_THE_BEDSIDE Lead Investigator Preclinical validation of novel implants for ligament reconstruction
  • 2015-2019 LIGAGEL2 Lead Investigator Novel hydrogel implants for ligament reconstruction
  • 2015-2017 HEMOSOFTCHEM Lead Investigator Soft matter chemistry for hemostasis
  • 2022-2027 CHROMA Scientific Director Optomechanics of nanostructured plasmonic microcapsules used as strain-stress sensors
  • 2022-2026 CARINGS Scientific Director Biomimetic hydrogels and aerogels for applications in osteoarticular medicine
  • 2021-2025 TRANSFERT LEARNING IN BIOMECHANICS Participant 3D vision and deep learning approaches applied to cross-species knee joint biomedical modeling

Teaching

Implantable Devices and Materials for Medical Use

Course Director

Syllabus The numerous and extremely varied concepts covered in this course will be illustrated by the teaching team using one or two real-life cases involving organs or tissues (dental, osteoarticular, cardiovascular, etc.) to serve as “guiding themes” throughout the course. During the first session, students will take on the role of an R&D team tasked with developing a material for a healthcare application. They will thus choose their own “guiding theme,” to which they will apply the various concepts covered from one class to the next. Each class session will be organized into three phases: - I - a presentation followed by a discussion during which a pair or trio of students will present how the material from the previous class applies to their project; - II - an introductory lecture on fundamental concepts or a presentation by a guest speaker (a physician, industry professional, or regulatory specialist); - III - a group work session to apply the concepts covered to the selected case study. Furthermore, once the case study has been selected, the teaching team will work with the students to contact one or more specialists in the field (physician, researcher, engineer, etc.), to whom a summary of the study will be presented at the end of the course in the form of a report and a project defense presentation. Students will thus be able to test their approach against the critical opinions of experts and professionals. Content The program will consist of six sessions during which the following concepts will be addressed: • the composition and organization of biological materials, • biocompatibility, bioactivity, biointegration, and bioresorbability, • the mechanical properties of tissues and their mechanical characterization in vivo and in vitro, • the major classes of biomaterials (polymers, metals, ceramics), • new manufacturing processes and the tissue engineering approach, • methods for evaluating the in-service performance of biomaterials and medical devices, • regulatory aspects, • consideration of medical constraints, • the industrial context.

Engineering and Health Research (Research Quarter)

Course Director

PhD supervision

  • 2025 Thermosensitive Bioactive Hydrogels for 3D Cell Culture GUEROUAZ Maëlys
  • 2024 Plasmonic microcapsules for detecting strain and stress in biological tissues ALVAREZ Karl
  • 2022 Multi-scale structural mechanisms of sol-gel transition in thermosensitive chitosan/β-glycerophosphate hydrogels POMMIER Louanne
  • 2022 Structure-mechanical relation in anisotropic poly(vinyl alcohol) hydrogel fibers for biomimetic soft tissue substitutes DIAZ COLINA Andrea
  • 2022 Advances in 3D vision and deep learning for shape analysis and synthesis: application to interspecies biomechanical modeling of the knee joint BASTICO Matteo
  • 2019 Films and adhesive particle coatings for surgery ROQUART Maïlie
  • 2019 Friction in hydrogel fibre assemblies and applications to soft tissue reconstruction MAEZTU REDIN Juan Deyo
  • 2018 Thermosensitive macroporous hydrogels for cell encapsulation and delivery DANG Phuong Anh
  • 2015 Study and design of assemblies of polyvinyl alcohol hydrogel fibers for ligament reconstruction CAROUX Julien
  • 2012 Elaboration et caracterisation de films d'hydrogel et de composites hydrogel-céramique pour les applications médicales MOREAU David