{"id":786,"date":"2025-07-15T11:18:39","date_gmt":"2025-07-15T09:18:39","guid":{"rendered":"https:\/\/www.minesparis.psl.eu\/cbio\/?page_id=786"},"modified":"2025-07-15T13:42:38","modified_gmt":"2025-07-15T11:42:38","slug":"research","status":"publish","type":"page","link":"https:\/\/www.minesparis.psl.eu\/cbio\/en\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n<div class=\"container\">\n\t<div class=\"row mt-4\">\n\t\t<div class=\"col-md-12\">\n\t\t\t<h2>Research areas<\/h2>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div class=\"container\">\n\t<div class=\"row mt-4\">\n\t\t<div class=\"col-md-6\">\n\t\t\t<h3 style=\"text-align: justify;\"><span style=\"color: #015d9e;\">Computational biology and statistical modeling<\/span><\/h3>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\"><strong>Development of machine learning methods to understand biological systems from multi-omic data:<\/strong><\/span><\/p>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"color: #000000;\">Modeling of the cell cycle, gene expr<\/span>ession profiles, and post-transcriptional regulation<\/li>\n<li style=\"text-align: justify;\">Study of molecular evolution and genomic structures (transposable elements, horizontal transfers, mutations)<\/li>\n<li style=\"text-align: justify;\">Classification of cell lines or tumor types<\/li>\n<li style=\"text-align: justify;\">Integration of heterogeneous data (RNA-seq, ATAC-seq, methylation, etc.)<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t<div class=\"col-md-6\">\n\t\t\t<h3 style=\"text-align: justify;\"><span style=\"color: #015d9e;\">Biomedical imaging and spatial bioinformatics<\/span><\/h3>\n<p style=\"text-align: justify;\"><strong>Application of computer vision techniques to analyze complex biological images:<\/strong><\/p>\n<ul>\n<li>Detection and classification of cellular or tissue structures<\/li>\n<li>Segmentation of images from spatial transcriptomics<\/li>\n<li>Morphological analysis in computational pathology<\/li>\n<li>Development of deep learning models on whole histological slides<\/li>\n<\/ul>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div class=\"container\">\n\t<div class=\"row mt-4\">\n\t\t<div class=\"col-md-6\">\n\t\t\t<h3 style=\"text-align: justify;\"><span style=\"color: #015d9e;\">Personalized and predictive medicine<\/span><\/h3>\n<p style=\"text-align: justify;\"><strong>Development of predictive models to anticipate treatment responses, detect biomarkers, and guide clinical decisions:<\/strong><\/p>\n<ul>\n<li>Analysis of multi-modal clinical and genomic data<\/li>\n<li>Prediction of survival or therapeutic benefit (e.g., bladder cancer)<\/li>\n<li>Early diagnosis strategies (e.g., lung cancer, Alzheimer&rsquo;s disease)<\/li>\n<li>Automated detection of complex phenotypes in patient cohorts<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t<div class=\"col-md-6\">\n\t\t\t<h3 style=\"text-align: justify;\"><span style=\"color: #015d9e;\">AI-assisted drug design<\/span><\/h3>\n<p style=\"text-align: justify;\"><strong>Use of machine learning and molecular docking for the rational design of active compounds:<\/strong><\/p>\n<ul>\n<li style=\"text-align: justify;\">Large-scale prediction of protein-ligand interactions (e.g., Komet algorithm)<\/li>\n<li style=\"text-align: justify;\">Exploration of chemical space and therapeutic targets<\/li>\n<li style=\"text-align: justify;\">Structural analysis of proteins and RNA with geometric deep learning<\/li>\n<li style=\"text-align: justify;\">Virtual screening for the discovery of therapeutic molecules<\/li>\n<\/ul>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div class=\"container\">\n\t<div class=\"row mt-4\">\n\t\t<div class=\"col-md-12\">\n\t\t\t<hr \/>\n<h2>Research projects<\/h2>\n<p><strong>The CBIO is conducting several major projects funded by national and European institutions, often in partnership with other research centers or clinical stakeholders.<\/strong><\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.minesparis.psl.eu\/cbio\/en\/research\/projects\/\" class=\"button-mines btn-bleu flech lf-blanc\">Discover all projects<\/a><\/p>\n\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":383,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-786","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.3.1 - 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