{"id":309,"date":"2025-05-22T16:35:10","date_gmt":"2025-05-22T14:35:10","guid":{"rendered":"https:\/\/www.minesparis.psl.eu\/cbio\/?page_id=309"},"modified":"2025-07-15T11:27:48","modified_gmt":"2025-07-15T09:27:48","slug":"recherche","status":"publish","type":"page","link":"https:\/\/www.minesparis.psl.eu\/cbio\/recherche\/","title":{"rendered":"Recherche"},"content":{"rendered":"\n<div class=\"container\">\n\t<div class=\"row mt-4\">\n\t\t<div class=\"col-md-12\">\n\t\t\t<h2>Les axes de recherche<\/h2>\n<p>&nbsp;<\/p>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div class=\"container\">\n\t<div class=\"row mt-4\">\n\t\t<div class=\"col-md-6\">\n\t\t\t<h3 style=\"text-align: left;\" data-start=\"1048\" data-end=\"1107\"><span style=\"color: #015d9e;\">Biologie computationnelle et mod\u00e9lisation statistique<\/span><\/h3>\n<p style=\"text-align: justify;\" data-start=\"1108\" data-end=\"1238\"><strong>D\u00e9veloppement de m\u00e9thodes d&rsquo;apprentissage automatique pour comprendre les syst\u00e8mes biologiques \u00e0 partir de donn\u00e9es multi-omiques :<\/strong><\/p>\n<ul>\n<li data-start=\"1241\" data-end=\"1351\">Mod\u00e9lisation du cycle cellulaire, des profils d&rsquo;expression g\u00e9nique et de la r\u00e9gulation post-transcriptionnelle<\/li>\n<li data-start=\"1354\" data-end=\"1475\">\u00c9tude de l\u2019\u00e9volution mol\u00e9culaire et des structures g\u00e9nomiques (\u00e9l\u00e9ments transposables, transferts horizontaux, mutations)<\/li>\n<li data-start=\"1478\" data-end=\"1538\">Classification de lign\u00e9es cellulaires ou de types de tumeurs<\/li>\n<li data-start=\"1541\" data-end=\"1611\">Int\u00e9gration de donn\u00e9es h\u00e9t\u00e9rog\u00e8nes (RNA-seq, ATAC-seq, m\u00e9thylation&#8230;)<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t<div class=\"col-md-6\">\n\t\t\t<h3 data-start=\"1613\" data-end=\"1668\"><span style=\"color: #015d9e;\">Imagerie biom\u00e9dicale et bio-informatique spatiale<\/span><\/h3>\n<p style=\"text-align: justify;\" data-start=\"1669\" data-end=\"1768\"><strong>Application de techniques de vision par ordinateur pour analyser des images biologiques complexes :<\/strong><\/p>\n<ul>\n<li data-start=\"1771\" data-end=\"1839\">D\u00e9tection et classification de structures cellulaires ou tissulaires<\/li>\n<li data-start=\"1842\" data-end=\"1899\">Segmentation d\u2019images issues de transcriptomique spatiale<\/li>\n<li data-start=\"1902\" data-end=\"1954\">Analyse morphologique en pathologie computationnelle<\/li>\n<li data-start=\"1957\" data-end=\"2035\">D\u00e9veloppement de mod\u00e8les de deep learning sur des lames histologiques enti\u00e8res<\/li>\n<\/ul>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div class=\"container\">\n\t<div class=\"row mt-4\">\n\t\t<div class=\"col-md-6\">\n\t\t\t<h3 style=\"text-align: justify;\" data-start=\"2037\" data-end=\"2079\"><span style=\"color: #015d9e;\">M\u00e9decine personnalis\u00e9e et pr\u00e9dictive<\/span><\/h3>\n<p style=\"text-align: justify;\" data-start=\"2080\" data-end=\"2222\"><strong>D\u00e9veloppement de mod\u00e8les pr\u00e9dictifs pour anticiper les r\u00e9ponses aux traitements, d\u00e9tecter des biomarqueurs et guider les d\u00e9cisions cliniques :<\/strong><\/p>\n<ul>\n<li style=\"text-align: left;\" data-start=\"2225\" data-end=\"2281\">Analyse de donn\u00e9es cliniques et g\u00e9nomiques multi-modales<\/li>\n<li style=\"text-align: left;\" data-start=\"2284\" data-end=\"2363\">Pr\u00e9diction de la survie ou du b\u00e9n\u00e9fice th\u00e9rapeutique (ex : cancer de la vessie)<\/li>\n<li style=\"text-align: left;\" data-start=\"2366\" data-end=\"2443\">Strat\u00e9gies de diagnostic pr\u00e9coce (ex : cancer du poumon, maladie d\u2019Alzheimer)<\/li>\n<li style=\"text-align: left;\" data-start=\"2446\" data-end=\"2521\">D\u00e9tection automatis\u00e9e de ph\u00e9notypes complexes dans les cohortes de patients<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t<div class=\"col-md-6\">\n\t\t\t<h3 data-start=\"2523\" data-end=\"2570\"><span style=\"color: #015d9e;\">Conception de m\u00e9dicaments assist\u00e9e par IA<\/span><\/h3>\n<p style=\"text-align: justify;\" data-start=\"2571\" data-end=\"2680\"><strong>Utilisation du machine learning et du docking mol\u00e9culaire pour la conception rationnelle de compos\u00e9s actifs :<\/strong><\/p>\n<ul>\n<li data-start=\"2683\" data-end=\"2769\">Pr\u00e9diction des interactions prot\u00e9ines-ligands \u00e0 grande \u00e9chelle (ex : algorithme Komet)<\/li>\n<li data-start=\"2772\" data-end=\"2833\">Exploration de l\u2019espace chimique et des cibles th\u00e9rapeutiques<\/li>\n<li data-start=\"2836\" data-end=\"2916\">Analyse structurale de prot\u00e9ines et d\u2019ARN avec apprentissage profond g\u00e9om\u00e9trique<\/li>\n<li data-start=\"2919\" data-end=\"2982\">Criblage virtuel pour la d\u00e9couverte de mol\u00e9cules th\u00e9rapeutiques<\/li>\n<\/ul>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div class=\"container\">\n\t<div class=\"row mt-4\">\n\t\t<div class=\"col-md-12\">\n\t\t\t<hr \/>\n<h2 data-start=\"2242\" data-end=\"2273\">Projets de recherche<\/h2>\n<p style=\"text-align: justify;\" data-start=\"2275\" data-end=\"2456\"><strong>Le CBIO m\u00e8ne plusieurs projets structurants, financ\u00e9s par des institutions nationales ou europ\u00e9ennes, souvent en partenariat avec d\u2019autres centres de recherche ou acteurs cliniques.<\/strong><\/p>\n<p data-start=\"2275\" data-end=\"2456\" style=\"text-align: center;\"><a class=\"button-mines btn-bleu flech lf-blanc\" href=\"https:\/\/www.minesparis.psl.eu\/cbio\/recherche\/projets-de-recherche\/\" target=\"_blank\" rel=\"noopener\">D\u00e9couvrir tous les projets<\/a><\/p>\n\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":383,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-309","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Recherche - CBIO<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.minesparis.psl.eu\/cbio\/recherche\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Recherche - CBIO\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.minesparis.psl.eu\/cbio\/recherche\/\" \/>\n<meta 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